A "microbial cell factory" is a microorganism re-engineered to convert renewable carbon — sugar, glycerol, methanol, CO₂ — into a high-value product. Our lab combines strain engineering, pathway design, and fermentation optimisation to push titre, rate, and yield (TRY) to industrially-relevant levels. Across E. coli, yeast, and select non-model microorganisms, our work spans:

• ▸ Genome integration site discovery for plasmid-free, stable strain construction.
• ▸ Tuneable expression systems (AUCS, MHP) for modular pathway control.
• ▸ Adaptive laboratory evolution (ALE) and high-throughput screening.
• ▸ Engineering fungal hosts (e.g. mushrooms) for novel terpene synthases.

Selected publications

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Representative figure

AUCS. A precision arabinose-inducible univariant gene-expression tool for tuneable microbial production of proteins, enzymes, and metabolites. 10.1021/acssynbio.5c00602